Some System BIOS' may not include the ability to disable USB devices from the Boot Order/Boot Sequence.

USB Keyboard or Mouse May Not Work After You Restart Your Computer in MS-DOS Mode.

Computer Hangs During Shutdown with USB Legacy Support Enabled in the BIOS.

Here are two Microsoft links that cover Disabling USB Legacy support.

Note: If you are using a USB mouse or Keyboard disabling legacy support may result in those devices not functioning in Real mode (MS-DOS) or Safe Mode. Note: Verbiage will vary from system to system Disable Boot from USB devices in the BIOS.If using exFAT is required, try one of the other options listed. If using on Windows only, then format the drive to NTFS.

For some systems this may present issues. Some Seagate drives ship as exFAT for Window and Mac compatibility. If it is then remove the active flag using these instructions.

Check to see if the active flag is set to active on the partition.

Here are some steps to try and resolve the issue:

Please refer to the system or motherboard manufacturer’s documentation for access and configuring options. Some of these steps require accessing the system’s BIOS. Issues booting while a USB drive is connected is usually the result of a USB Device option being enabled in the System BIOS' Boot Order or Boot Sequence.

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How to check if usb is bootable